Information for
Clinicians

Study Criteria

KPMP enrolls participants with CKD or AKI. CKD participants may have diabetic kidney disease or hypertensive kidney disease. Inclusion criteria for each study cohort and the general exclusion critieria is listed below.

Inclusion

Diabetic Kidney Disease (Type 1 or 2)

• eGFR 30-59mL/min/1.73m2 OR
• eGFR ≥ 60 with UPCR >150mg/g or UACR >30 mg/g

Hypertensive Kidney Disease

• eGFR30-59/min/1.73m2 with UPCR or UACR <2000 mg/g  OR
• eGFR ≥ 60 with UACR 30-2000mg/g or UPCR 150-2000 mg/g

Acute Kidney Injury

• Baseline eGFR >45mL/min/1.73m2
• Elevated serum creatinine ≥1.5x baseline, AND one of the following:
• Further serum creatinine increase of 0.3 mg/dL
• Positive kidney injury urine biomarkers (NGAL, Kim1, TIMP2 x IGFBP7)
• Urine microscopy suggestive of ATN

Exclusion

• Age <18
• Glomerular disease, Kidney transplant, Pregnancy
• Increased biopsy complication risk
  (Kidney depth >13cm, Kidney size <8cm, Solitary kidney, multiple kidney cysts, chronic anticoagulation, platelets <100, , INR >1.4, Hgb <9, BP>140/90)

Study procedures

KPMP participants are asked to do the following:‍

• Have a biopsy of their kidney for research purposes.
• Give blood, urine and stool.
• Provide our study team with information about them.
• Talk to our study team 2-3 times a year for up to 10 years.

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