Information for
Clinicians

Clinical caregivers are central to advances for patients with kidney diseases. As key stakeholders, clinicians can increase awareness and participation in the KPMP. Readily available study information and videos of patient experiences are provided to bring the KPMP to a broad clinical community.

Study Criteria

KPMP enrolls participants with CKD or AKI. CKD participants may have diabetic kidney disease or hypertensive kidney disease. Inclusion criteria for each study cohort and the general exclusion critieria is listed below.

Inclusion

Diabetic Kidney Disease (Type 1 or 2)

  • eGFR 30-59mL/min/1.73m2 OR
  • eGFR ≥ 60 with UPCR >150mg/g or UACR >30 mg/g

Hypertensive Kidney Disease

  • eGFR30-59/min/1.73m2 with UPCR or UACR
  • eGFR ≥ 60 with UACR 30-2000mg/g or UPCR 150-2000 mg/g

Acute Kidney Injury

  • Baseline eGFR >45mL/min/1.73m2
  • Elevated serum creatinine ≥1.5x baseline, AND one of the following:
  • Further serum creatinine increase of 0.3 mg/dL
  • Positive kidney injury urine biomarkers (NGAL, Kim1, TIMP2 x IGFBP7)
  • Urine microscopy suggestive of ATN

Healthy Reference Groups

  • Undergoing percutaneous nephrolithotomy for treatment of symptomatic renal stones without evidence of pyelonephritis
  • Participating in a living donor kidney transplantation as the donor

Exclusion

  • Age (<18 years)
  • Glomerular disease, Kidney transplant, Pregnancy
  • Increased biopsy complication risk (Chronic anticoagulation, Platelets <100, INR>1.4, Hb <9, aspirin intake within 7 days of biopsy, Hypotension or BP that cannot be controlled to >160/100mmHg at time of biopsy).

Study procedures

KPMP participants are asked to do the following:

  • Have a biopsy of their kidney for research purposes.
  • Give blood, urine and stool.
  • Provide our study team with information about them.
  • Talk to our study team 2-3 times a year for up to 10 years.

Clinician Resources

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Clinician Primer

Information about the study for clinicians

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Brochure

Informational brochure for patients

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FAQ

Frequently asked questions for patients

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Presentation

KPMP Overview Powerpoint presentation

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AKI Fact sheet

Talking points brochure for clinicians with AKI patients

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CKD fact sheet

Talking points brochure for clinicians with CKD patients

Site Contacts

If you have a patient who would be a good candidate for KPMP, you can reach out to your nearest study center for more information.

Chronic Kidney Disease (CKD)

Boston, MA
Joslin Diabetes Center/Beth Israel Deaconess Medical Center
Email research coordinator
(617) 309-4130
Site investigator:
Sylvia Rosas, MD
Boston, MA
Brigham and Women’s Hospital
Email research coordinator
(617) 638-7332
Site investigator:
Sushrut Waikar, MD, MPH
Cleveland, OH
Cleveland Clinic
Email research coordinator
(216) 444-7954
Site investigator:
John Sedor, MD
Dallas, TX
University of Texas Southwestern, Dallas
Email research coordinator
‍(214) 615-8291
Site investigator:
Miguel Vasquez, MD

Acute Kidney Injury (AKI)

New Haven, CT
Yale University
Email research coordinator
‍‍(203) 737-1787
Site investigator:
F. Perry Wilson, MD
Boston, MA
Boston University
Email research coordinator
Site investigator:
Sushrut Waikar, MD, MPH
Baltimore, Maryland
Johns Hopkins
Email research coordinator
(410) 955-3852
Site investigator:
Chirag Parikh, MD, PhD
New York, NY
Columbia University
Email research coordinator
(212) 851-5216
Site investigator:
Krzyzstof Kiryluk, MD
Pittsburgh, PA
University of Pittsburgh
Email research coordinator
(412) 958-0957
Site investigator:
Paul Palevsky, MD

Get involved

We value the input of clinicians as we work to grow our study. The KPMP Community Engagement Committee is made up of KPMP site members,patient partners, ethicists and community clinicians. The group meets monthly to receive updates on the study and discuss issues of interest.

If you are interested in participating in the KPMP Community Engagement Committee, please reach out to Ashveena Dighe (ashveena@uw.edu)

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