Dear KPMP Participant,

Thank you for joining us on this journey! We have some exciting news to share with you.

Since the first KPMP kidney biopsy in late 2019, researchers have been working hard to learn from the samples and information you have given. We want to tell you about some of the progress we’ve made.

Some KPMP research looks closely at individual participants—just like you. Here are two easy-to-understand stories about how your help is making a difference for kidney care. Don’t worry—your personal information is always kept private

1. New Blood Vessels in Kidneys with Diabetes

Original Article Title: “Molecular Signatures of Glomerular Neovascularization in a Patient with Diabetic Kidney Disease”
‍

Simple Title: “Signs of New Blood Vessels Growing in the Kidney Filters of a Person with Diabetes”

What Did Researchers Do?

• Scientists used special 3D pictures and tests to look at a diabetic patient’s kidney.
• They found new, tiny blood vessels growing in the kidney filters where they usually don’t grow.
• They checked which genes were turned on to help build these new blood vessels.

Why Does This Matter?

• Doctors’ regular tests often miss these new blood vessels in people with diabetes and kidney problems.
• In the future, doctors may find kidney damage sooner by looking for extra blood vessels and the genes that make them.
• These new tests are not used everywhere yet, but this research shows why they are important.
• Finding problems early means patients can start treatment sooner. This may help kidneys stay healthy longer and delay the need for dialysis.

‍

2. How Kidneys Get Hurt and Heal

Original Article Title: “Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation”
‍

Simple Title: “Looking at Kidney Cells and Tissue to Learn How They Get Hurt and Heal After Sudden Injury.”

What Did Scientists Do?

• Researchers studied a patient’s damaged kidney one cell at a time and looked at the tissue under a microscope.
• They saw that even cells of the same kind can get hurt and heal in different ways in the same kidney.

Why Does This Matter?

• This shows that kidney injury and healing are not the same everywhere in the kidney.
• In the future, doctors may be able to choose the best treatment for each person, based on how their kidneys heal.
• We hope this helps people’s kidneys stay strong for longer and keeps them healthier.

Why Study One Patient So Closely?

Looking at one person’s kidney very carefully helps scientists answer important questions.

• In the first story, scientists tested new tools to see if they could find important clues that regular tests miss.
• In the second story, they made a detailed map of how kidney cells get hurt and try to fix themselves.

‍

Want to Learn More?

We have shared some of the findings and what they mean for you. There is a lot more to learn! You can find these articles on our KPMP website.

Let us know what you think! If you enjoyed this, we will share more research highlights in future updates.

‍

Atlas Metrics:

598 Biopsies    |     >256K Data downloads     |     59 Publications

‍

Want to attend one of the All-KPMP meetings virtually or in-person?

Ask your site's research coordinator how you can attend an upcoming meeting. This meeting is attended by many members of the KPMP team. We would love to see you there!

Upcoming All-KPMP meetings: (virtual or in-person)

• September 30 & October 1, 2025 (Kellogg Conference Center at Gallaudet University)

‍

Tell a friend…

Do you have family, friends or co-workers who might be interested in
learning about KPMP? Please give them this link to the KPMP Introduction video:
kpmp.org/for-participants

‍

Sincerely,