How to cite data used from the KPMP

The results here are in whole or part based upon data generated by KPMP:  DK133081, DK133091, DK133092,DK133093, DK133095, DK1330971, DK114866, DK114908, DK133090, DK133113,DK133766, DK133768, DK114907, DK114920, DK114923, DK114933, DK114886. https://www.kpmp.org.

Data downloaded on [date]

Citing KPMP data

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Introduction

The Kidney Precision Medicine Project (KPMP) is a prospective cohort study, whose goal is to use deep molecular phenotypes of kidney biopsies, along with longitudinally collected clinical phenotypic data, in order to develop new disease ontologies, classification systems, and treatments for acute kidney injury (AKI) and chronic kidney disease (CKD).

For each participant, kidney tissue is obtained for molecular phenotyping and clinical diagnosis. In addition to the kidney biopsy tissue, the study collects baseline (time of biopsy) and longitudinal biospecimens (including urine, plasma, serum, DNA, and stool) and demographic, clinical, and laboratory data.

Participant Population

The KPMP is focusing on participants with acute and chronic kidney disease, who account for a large portion of the public health concern as reported by research and federal data.

For CKD, high priority populations include CKD in the setting of diabetes (diabetic kidney disease (DKD)) and hypertension-associated CKD (H-CKD). For AKI, the focus will be on acute intrinsic non-glomerular disease, primarily on acute tubular necrosis (ATN). 

Inclusion / Exclusion Criteria

Inclusion:

  • Diabetic Kidney Disease (Type 1 or 2)
  • Hypertensive Kidney Disease
  • Acute Kidney Injury

Exclusion:

  • Age (under 18)
  • Glomerular disease, kidney transplant, malignancy, pregnancy
  • Increased biopsy complication risk

For more specific details regarding inclusion and exclusion criteria for our various study populations, see the full clinical protocol on the KPMP website.

Cite KPMP in your publications

See: Citing KPMP data

Introduction

Biopsy Processing and Distribution

The goal for KPMP ideally is to obtain 3 cores from each participant, which allows for multiple -omics technologies to be run on the same participant (though on different core samples). Core 1 is used for diagnostic purposes; Cores 2 and 3 are solely used for research:

For more information about the current triage process for the biopsy cores, see the pathology protocol on the KPMP website.


Biopsy processing and distribution

KPMP Data Types

Clinical data

There is a wide variety of clinical phenotype data being collected about each participant in the KPMP, including longitudinal follow-up data. The KPMP REDCap codebook outlines all of the collected clinical phenotype data. View the REDCap Codebook.

Pathology data

KPMP biopsy tissue is processed for light microscopy, immunofluorescence microscopy, and electron microscopy. Standard light microscopic stains for the KPMP tissue are: H&E, PAS, trichrome, and Jones' silver. The light microscopy whole slide images are available for download in the Atlas Data Repository (here).

See the pathology protocol for more details on the pathology workflow.

Molecular data

Several tissue interrogation technologies are active in the KPMP. To maximize impact of the limited kidney tissue, participating sites are required to submit their technology for a review of feasibility, reproducibility, rigor, and value of the technology to achieve the goals of the KPMP. The table below lists all of the omics and imaging technologies that are approved and actively analyzing kidney biopsy tissue. The multimodal techniques applied on KPMP biopsies are expected to evolve over time.

To learn more about each tissue interrogation approach, see the Technologies section.

See all available data in KPMP

Approved tissue interrogation technologies

OMICS TYPE TECHNOLOGY
Transcriptomics Single-nucleus RNA-seq
Single-cell RNA-seq
Regional transcriptomics
Spatial transcriptomics
Proteomics Regional proteomics
Metabolomics Spatial metabolomics
Spatial lipidomics
Imaging 3D tissue imaging and cytometry
CODEX

Metadata standards

The Kidney Precision Medicine Project is generating a large amount of data. To enable data accessibility and interoperability, each dataset that is generated must be accompanied by a standard set of metadata. The required metadata properties vary by technology. For the metadata properties being collected for all of the KPMP technologies, refer to the Metadata page to see all of the metadata templates.

Data types

How to cite data used from the KPMP

The results here are in whole or part based upon data generated by KPMP:  DK133081, DK133091, DK133092,DK133093, DK133095, DK1330971, DK114866, DK114908, DK133090, DK133113,DK133766, DK133768, DK114907, DK114920, DK114923, DK114933, DK114886. https://www.kpmp.org.

Data downloaded on [date]

Citing KPMP data

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