Study overview

Introduction to KPMP

TL;DR:

What the KPMP is, who takes part, the inclusion and exclusion criteria, and how to cite the KPMP in publications.

The Kidney Precision Medicine Project (KPMP) is a prospective cohort study, whose goal is to use deep molecular phenotypes of kidney biopsies, along with longitudinally collected clinical phenotypic data, in order to develop new disease ontologies, classification systems, and treatments for acute kidney injury (AKI) and chronic kidney disease (CKD).

For each participant, kidney tissue is obtained for molecular phenotyping and clinical diagnosis. In addition to the kidney biopsy tissue, the study collects baseline (time of biopsy) and longitudinal biospecimens (including urine, plasma, serum, DNA, and stool) and demographic, clinical, and laboratory data.

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Participant Population

The KPMP is focusing on participants with acute and chronic kidney disease, who account for a large portion of the public health concern as reported by research and federal data.

CKD

  • High priority populations include CKD in the setting of diabetes (diabetic kidney disease, DKD) and hypertension-associated CKD (H-CKD).

DM-R

  • A special population of people with long-standing type 1 diabetes (more than 25 years) who remain free of clinically-evident DKD (i.e. diabetes mellitus-resilient (DM-R) individuals also known as “Resistors”) will also be included. Study of the DM-R population using KPMP protocols offers a unique opportunity to identify protective factors against complications of diabetes mellitus.

AKI

  • The focus will be on acute intrinsic non-glomerular disease, primarily on acute tubular necrosis (ATN). 

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Inclusion / Exclusion Criteria

Inclusion:

  • Diabetic Kidney Disease (Type 1 or 2)
  • Hypertensive Kidney Disease
  • Acute Kidney Injury
  • Patient has had diabetes for many years but no clinical indications of CKD

Exclusion:

  • Age (under 18)
  • Glomerular disease, kidney transplant, malignancy, pregnancy
  • Increased biopsy complication risk

For more specific details regarding inclusion and exclusion criteria for our various study populations, see the full clinical protocol on the KPMP website.

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Cite KPMP in your publications

See: Citing KPMP data